Cell Signaling Meis1/2 Antibody

Name: Cell Signaling Meis1/2 Antibody
SKU: CSIG-12744S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Meis1/2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12744S

MFG.PART: 12744S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Transfected Only
Molecular Weight (kDa)	50, 70
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MEIS1/2 Antibody recognizes transfected levels of total MEIS1 and MEIS2 proteins.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MEIS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Hox, Pbx, and Meis are families of transcription factors that bind DNA via their homeodomains. Members from each family form heterodimers to give rise to complexes with unique DNA binding specificities. Homeodomain containing proteins are frequently involved in normal developmental processes, but can also be associated with tumorigenic states (1). MEIS proteins belong to the TALE (Three Amino Acid Loop Extension) homeobox containing transcription factor family. MEIS1 has been associated with leukemogenesis and neuroblastoma (2,3) while MEIS2 is known to play an important role in the transcriptional program that is induced in normal pancreatic development (4) and cardiogenesis (5).

Specifications