Cell Signaling Nkx2.2 Antibody

Name: Cell Signaling Nkx2.2 Antibody
SKU: CSIG-12310S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Nkx2.2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12310S

MFG.PART: 12310S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Transfected Only
Molecular Weight (kDa)	40
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	NKX2.2 Antibody recognizes transfected levels of total NKX2.2 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala92 of human NKX2.2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The NKX family of homeobox genes are known to act as intermediaries in the neural response to Sonic hedgehog signaling during central nervous system development (1). NKX2.2 is a member of this family of transcription factors and is necessary for neuroendocrine differentiation in the central nervous system and pancreas (2,3). NKX2.2 mutant mice die shortly after birth due to incomplete differentiation of insulin-producing pancreatic β cells and defects in ventral neural patterning (2,3). According to the research literature, expression of NKX2.2 has also been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors (4).

Specifications