Cell Signaling Lamtor4/C7orf59 (D6a4v) Rabbit mAb

Name: Cell Signaling Lamtor4/C7orf59 (D6a4v) Rabbit mAb
SKU: CSIG-12284S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Lamtor4/C7orf59 (D6a4v) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12284S

MFG.PART: 12284S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	11
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunofluorescence (Immunocytochemistry): 1:800}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LAMTOR4/C7orf59 (D6A4V) Rabbit mAb recognizes endogenous levels of total LAMTOR4/C7orf59 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LAMTOR4/C7orf59 protein.
Background	Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4 (LAMTOR4) is an essential component of the ragulator protein complex that is encoded by the C7orf59 gene (1). The ragulator complex also includes LAMTOR1/C11orf59, LAMTOR2/ROBLD3, LAMTOR3/MAPKSP1, and HBXIP (1,2). This pentameric protein complex localizes to the lysosomal membrane and is essential for the lysosomal localization of Rag GTPases and mTORC1 as well as the subsequent activation of mTORC1 in response to amino acid signaling (1-3).

Specifications