Cell Signaling Il-1beta (3a6) Mouse mAb

Name: Cell Signaling Il-1beta (3a6) Mouse mAb
SKU: CSIG-12242S
Price: 347.44 USD

List Price $347.44 Your Price $347.44

Cell Signaling Il-1beta (3a6) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12242S

MFG.PART: 12242S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	17,31
Source/Isotype	Mouse IgG1
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #27989.
Specificity/Sensitivity	IL-1β (3A6) Mouse mAb recognizes endogenous levels of total IL-1β protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human IL-1β protein.
Background	Interleukin-1β (IL-1β), one of the major caspase-1 targets, is a multifunctional cytokine that is involved in a host of immune and proinflammatory responses (1). It is produced primarily by activated monocytes and macrophages. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets (2-6). Human IL-1β is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form (7,8). Detection of the 17 kDa mature form of IL-1β is a good indicator of caspase-1 activity.

Specifications