Cell Signaling Il-4 (D19a10) Rabbit mAb

Name: Cell Signaling Il-4 (D19a10) Rabbit mAb
SKU: CSIG-12227S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Il-4 (D19a10) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12227S

MFG.PART: 12227S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	17
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Flow Cytometry (Fixed/Permeabilized): 1:800}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	IL-4 (D19A10) Rabbit mAb recognizes endogenous levels of total IL-4 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human IL-4 protein.
Background	Interleukin-4 (IL-4) is a cytokine secreted by activated T cells, basophils, and mast cells (1,2). While it contributes to many immunomodulatory responses, it is mainly recognized as the cytokine responsible for eliciting differentiation of naive T cells into Th2 lineage cells that are defined by their secretion of IL-4, IL-5, and IL-10 (3). In addition, IL-4 contributes to immunoglobulin class switching by inducing the production of IgE from B cells (4,5). IL-4 acts through the IL-4 receptor, leading to tyrosine phosphorylation and activation of the Stat6 transcription factor (6).

Specifications