Cell Signaling Pgam1 (D3j9t) Rabbit mAb

Name: Cell Signaling Pgam1 (D3j9t) Rabbit mAb
SKU: CSIG-12098S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Pgam1 (D3j9t) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12098S

MFG.PART: 12098S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Hm Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	28
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PGAM1 (D3J9T) Rabbit mAb recognizes endogenous levels of total PGAM1 protein. This antibody may cross react with overexpressed PGAM2 protein.
Species Reactivity	Human, Mouse, Rat, Hamster, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PGAM1 protein.
Background	Phosphoglycerate mutase (PGAM1) catalyzes the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis (1-5). Research studies have shown increased PGAM1 expression in cancer (1-4) and mental disease (5). Specifically, PGAM1 was shown to be phosphorylated at His11 by phosphoenolpyruvate (PEP) in PKM2-expressing cells, suggesting a possible regulatory role for PGAM1 in actively proliferating cells via an alternative glycolytic pathway (1).

Specifications