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Cell Signaling Foxk2 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Foxk2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-12008S
MFG.PART:
12008S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 79 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | FoxK2 Antibody recognizes endogenous levels of total FoxK2 protein. |
| Species Reactivity | Human, Monkey |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human FoxK2 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | Forkhead box (Fox) proteins are a family of evolutionarily conserved transcription factors defined by the presence of a winged helix DNA binding domain called a Forkhead box (1). In humans, there are over 40 known Fox protein family members, divided into 19 subfamilies, which have evolved to regulate gene transcription in diverse and highly specialized biological contexts throughout development (2). Mutations that disrupt the expression of Fox gene family members have consequently been implicated in a broad array of human disorders, including immunological dysfunction, infertility, speech/language disorders, and cancer (3,4).FoxK1 and FoxK2 belong to one of the subfamilies of Fox proteins and contain a forkhead-associated (FHA) domain and a conserved forkhead DNA binding domain (5). FoxK2 was initially identified as a regulator of IL-2 transcription (6). Studies have shown that FoxK2 binds to DNA harboring G/T mismatches and might be involved in DNA mismatch repair (7). FoxK2 also mediates the oncogenic function of adenovirus (Adv) oncoprotein E1A and papillomavirus E6 proteins via association with these proteins (8). Moreover, FoxK2 promotes AP-1-mediated transcriptional regulation by enhancing the recruitment of AP-1 to chromatin (9). FoxK2 is phosphorylated at Ser368 and Ser423 in a CDK1-cyclin B-dependent manner and is involved in cell cycle regulation (10). |
| SKU | CSIG-12008S |
|---|---|
| Featured | No |
| Supplier Part Number | 12008S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |