Cell Signaling Sstr1 Antibody

Name: Cell Signaling Sstr1 Antibody
SKU: CSIG-11830S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Sstr1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-11830S

MFG.PART: 11830S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	R
Sensitivity	Endogenous
Molecular Weight (kDa)	40, 80
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SSTR1 Antibody recognizes endogenous levels of total SSTR1 protein.
Species Reactivity	Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val365 of human SSTR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Somatostatin receptors are part of the super family of G protein-coupled receptors. Five genes encoding six different somatostatin receptor subtypes (SSTR1, SSTR2A, SSTR2B, SSTR3, SSTR4, and SSTR5) have been cloned (1). Somatostatin receptors are activated by somatostatin, a neuropeptide that acts as a neurotransmitter in the brain that regulates hormone secretion from endocrine tissues (2). Somatostatin receptors are found to be highly expressed on human neuroendocrine tumors (3).mRNA expression data and immunohistochemical studies indicate high expression of SSTR1 in pituitary and gastroenteropancreatic tumor, renal, colorectal and breast cancer, meningioma, glioma neuroblastoma, and pheochromocytoma (3).

Specifications