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Cell Signaling Arrestin 1/S-Arrestin Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Arrestin 1/S-Arrestin Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-11828S
MFG.PART:
11828S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 52 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Arrestin 1/S-Arrestin Antibody recognizes endogenous levels of total Arrestin 1/S-Arrestin protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala163 of human Arrestin 1/S-Arrestin protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | Arrestin proteins function as negative regulators of G protein-coupled receptor (GPCR) signaling. Cognate ligand binding stimulates GPCR phosphorylation, which is followed by binding of arrestin to the phosphorylated GPCR and the eventual internalization of the receptor and desensitization of GPCR signaling (1). Four distinct mammalian arrestin proteins are known. Arrestin 1 (also known as S-arrestin) and arrestin 4 (X-arrestin) are localized to retinal rods and cones, respectively. Arrestin 2 (also known as β-arrestin 1) and arrestin 3 (β-arrestin 2) are ubiquitously expressed and bind to most GPCRs (2). β-arrestins function as adaptor and scaffold proteins and play important roles in other processes, such as recruiting c-Src family proteins to GPCRs in Erk activation pathways (3,4). β-arrestins are also involved in some receptor tyrosine kinase signaling pathways (5-8). Additional evidence suggests that β-arrestins translocate to the nucleus and help regulate transcription by binding transcriptional cofactors (9,10).Arrestin 1/S-Arrestin inactivates rhodopsin-mediated signaling through binding to the light-activated phosphorylated rod photoreceptor, thereby preventing coupling to transducin, rhodopsins cognate G protein (11). Research studies have proposed that mutations in the Arrestin 1/S-Arrestin gene are linked to Oguchi disease (12,13) and Retinitis Pigmentosa (14). |
| SKU | CSIG-11828S |
|---|---|
| Featured | No |
| Supplier Part Number | 11828S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |