Cell Signaling Synapsin-1 (D12g5) Xp Rabbit mAb (Alexa Fluor 647 Conjugate)

Name: Cell Signaling Synapsin-1 (D12g5) Xp Rabbit mAb (Alexa Fluor 647 Conjugate)
SKU: CSIG-11127S
Price: 454.50 USD

List Price $454.50 Your Price $454.50

Cell Signaling Synapsin-1 (D12g5) Xp Rabbit mAb (Alexa Fluor 647 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-11127S

MFG.PART: 11127S

UNSPSC: 12352200

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Frozen): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/ml BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Synapsin-1 (D12G5) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) detects endogenous levels of total synapsin protein. The antigen is 100% conserved between human synapsin-1a and synapsin-1b.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln483 of human synapsin-1 protein.
Background	Synapsins, a group of at least five related members (synapsins Ia, Ib, IIa, IIb, and IIIa), are abundant brain proteins essential for regulating neurotransmitter release (1,2). All synapsins contain a short amino-terminal domain that is highly conserved and phosphorylated by PKA or CaM kinase I (1). Phosphorylation of the synapsin amino-terminal domain at Ser9 inhibits its binding to phospholipids and dissociates synapsins from synaptic vesicles (2).

Specifications