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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB | Rb | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB2232 |
| Description | Anti-Atrial Natriuretic Polypetide Antibody, alpha |
| Alternate Names |
|
| Background Information | Atrial natriuretic polypeptide, alpha (ANP), atrial natriuretic factor (ANF), or atriopeptin, is a protein (polypeptide) hormone secreted by heart muscle cells. It is involved in the homeostatic control of body water, sodium, potassium and fat (adiposity). It is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes), in response to high blood pressure. ANP acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP binds to a specific set of receptors - ANP receptors. Receptor-agonist binding causes a reduction in blood volume and therefore a reduction in cardiac output and systemic blood pressure. Lipolysis is increased and renal sodium reabsorption is decreased. The overall effect of ANP on the body is to counter increases in blood pressure and volume caused by the renin-angiotensin system (1). |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purified in 0.1M Tris-Glycine (pH7.4) 15mM NaCl with 0.05% NaN3 |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Atrial Natriuretic Polypetide Antibody, alpha is validated for use in WB for the detection of Atrial Natriuretic Polypetide. |
| Key Applications |
|
| Application Notes | Non-Lot Specific Tested Application 1: Immunohistochemistry: 1:50-1:500 on paraffin embedded tissue. Optimum dilutions need to be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Synthetic Linear Peptide |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | Cat. # AB2232 recognizes ANP, alpha |
| Species Reactivity |
|
| Species Reactivity Note | Rat, Human and Mouse. May react with dog, cat and cow based on sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Purified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: A potent vasoactive substance which is thought to play a key role in cardiovascular homeostasis. Has a cGMP-stimulating activity. SUBUNIT: Interacts with NPR3. LOCATION: Secreted. POLYMORPHISM: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide. SIMILARITY: Belongs to the natriuretic peptide family. |
| Molecular Weight | ~17 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated by western blot |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |