Special Offers
100% Performance Guaranteed
Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | WB | Gp | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB2204 |
| Description | Anti-BMAL1 Antibody |
| Alternate Names |
|
| Background Information | Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock. |
| Product Information | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Serum with 0.05% NaN3 |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-BMAL1 Antibody is an antibody against BMAL1 for use in WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Recombinant Protein |
| Epitope | C-Terminus |
| Host | Guinea Pig |
| Specificity | Cat. # AB2204 will recognize the C-terminus of BMAL1. |
| Species Reactivity |
|
| Species Reactivity Note | Mouse, Human and Rat. Reactivity with other species has not been tested. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: ARNTL-CLOCK heterodimers activate E-box element (3-CACGTG-5) transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity). SUBUNIT: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo. SUBCELLULAR LOCATION: Nucleus (By similarity). ALTERNATIVE PRODUCTS: 8 named isoforms [FASTA] produced by alternative splicing. Additional isoforms seem to exist. |
| Molecular Weight | ~69 kDa. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely tested on C2C12 tissue lysate Lot Specific Tested Application 1: Western Blot |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 50 µL |