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Members of the evolutionarily conserved Mastermind (MAM) protein family, including the three related mammalian Mastermind-like (MAML) proteins MAML1–3, function as crucial coactivators of Notch-mediated transcriptional activation. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
Product Information
Format
Serum
Control
Tested by Western Blot on HEK293 cell lysate.
Presentation
Serum with 0.05% NaN3
Quality Level
MQ100
Applications
Application
This Anti-MAML1 Antibody is validated for use in WB for the detection of MAML1.
Key Applications
Western Blotting
Application Notes
MAML1 can be detected at 1/1000 dilution in 10 µg of HEK293 cell Lysate.
Biological Information
Immunogen
Synthetic Linear Peptide.
Host
Rabbit
Specificity
Cat. # AB15546 recognizes MAML1 protein.
Species Reactivity
Human
Species Reactivity Note
Reactivity with other species has not been tested.
Antibody Type
Polyclonal Antibody
Gene Symbol
MAML1
MAM1
KIAA0200
Mam1
Mam-1
UniProt Number
Q92585
Molecular Weight
108 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
