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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, Mk | IHC, WB | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB5802 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Dopamine Transporter Antibody, extracellular Loop 2 |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Affinity purified immunoglobulin. Each vial contains ~33 μg of affinity-purified antibody in 100 μL of 10 mM HEPES (pH 7.5), 150 mM NaCl with 100 μg/mL BSA and 50% glycerol. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Dopamine Transporter Antibody, extracellular Loop 2 is an antibody against Dopamine Transporter for use in IH & WB. |
| Key Applications |
|
| Application Notes | Immunoblotting: 1:500-1:1,000 Immunohistochemistry using formaldehyde-fixed brain sections: 1:500-1:1,000 Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Synthetic peptide from the EL2 region of human dopamine transporter. |
| Epitope | extracellular Loop 2 |
| Host | Rabbit |
| Specificity | Dopamine Transporter, Extracellular loop 2 (EL2). |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | The dopamine transporter (DAT1) mediates the active reuptake of dopamine from the synapse and is a principal regulator of dopaminergic neurotransmission. The DAT1 gene has been implicated in human disorders such as parkinsonism, Tourette syndrome, and substance abuse (Vandenbergh et al., 1992 [PubMed 1359373]).[supplied by OMIM] |
| Gene Symbol |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q01959 # Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. SIZE: 620 amino acids; 68495 Da SUBUNIT: Homooligomer; disulfide-linked. Interacts with PRKCABP and TGFB1I1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. SIMILARITY: SwissProt: Q01959 ## Belongs to the sodium:neurotransmitter symporter (SNF) family. MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20 to -80°C in undiluted aliquots for up to six months. Store in a NON-self-defrosting freezer. Avoid repeated freeze-thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |