Cayman Jnj-303; 50 Mg; 878489-28-2; ≥98%

JNJ-303 is an inhibitor of voltage-gated potassium channel K_v7.1 (IC₅₀ = 0.064 µM).¹ It is selective for inhibiting K_v7.1 currents (I_Ks) over I_Na, I_Kr, I_to, I_K1, and I_CaL (IC₅₀s =3.3, 12.6, 11.1, >100, and >10 µM, respectively). It selectively inhibits the heteromeric K_v7.1-KCNE1 complex (IC₅₀ = 0.0784 µM) with no effect on homomeric K_v7.1, K_v7.2, or K_v1.5 in Xenopus oocytes at 1 µM.² JNJ-303 prolongs the QT interval and also induces pause-dependent torsade de pointes (TdP) in anesthetized dogs when used at doses of 0.63 and 1.25 mg/kg, respectively.¹

WARNING This product is not for human or veterinary use.