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Cayman Jnj-303; 50 Mg; 878489-28-2; ≥98%
List Price
$956.00
Your Price
$956.00
Cayman Jnj-303; 50 Mg; 878489-28-2; ≥98% - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-37345-50
MFG.PART:
37345-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
JNJ-303 is an inhibitor of voltage-gated potassium channel Kv7.1 (IC50 = 0.064 µM).1 It is selective for inhibiting Kv7.1 currents (IKs) over INa, IKr, Ito, IK1, and ICaL (IC50s =3.3, 12.6, 11.1, >100, and >10 µM, respectively). It selectively inhibits the heteromeric Kv7.1-KCNE1 complex (IC50 = 0.0784 µM) with no effect on homomeric Kv7.1, Kv7.2, or Kv1.5 in Xenopus oocytes at 1 µM.2 JNJ-303 prolongs the QT interval and also induces pause-dependent torsade de pointes (TdP) in anesthetized dogs when used at doses of 0.63 and 1.25 mg/kg, respectively.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(4-chloro phenoxy)-2- methyl-N-[5- [(methyl sulfonyl) amino]tricyclo [3.3.1.13,7] dec-2-yl]- propanamide, stereoisomer
CAS Number
878489-28-2
Molecular Formula
C21H29ClN2O4S
Formula Weight
441.0
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMF: 1 mg/ml
- DMSO: 1 mg/ml
- Ethanol: insol
- PBS (pH 7.2): insol
λmax
225 nm
SMILES
O=C(C(C)(C)OC(C=C1)=CC=C1Cl)N[C@@H]([C@@H]2C3)[C@H](C[C@@H]4C2)C[C@@]3(C4)N[S](C)(=O)=O
InChi Code
InChI=1S/C21H29ClN2O4S/c1-20(2,28-17-6-4-16(22)5-7-17)19(25)23-18-14-8-13-9-15(18)12-21(10-13,11-14)24-29(3,26)27/h4-7,13-15,18,24H,8-12H2,1-3H3,(H,23,25)/t13-,14-,15+,18-,21-
InChi Key
OSGIRCJRKSAODN-HPMFMUNCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-37345-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 37345-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 878489-28-2 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |