Cayman Idr 1002 (Trifluoroacetate Salt); 10 Mg; ≥95%

ML-154 is an antagonist of the neuropeptide S receptor (NPSR; IC₅₀ = 3.5 nM). It is selective for NPSR over arginine vasopressin (AVP) receptor V_1B, as well as a panel of 55 receptors, channels, and transporters at 10 µM.^, ML-154 reduces NPS-induced calcium mobilization, cAMP formation, and ERK activation with IC₅₀ values of 0.96, 45, and 1.3 nM, respectively, in CHO cells expressing NPSR. It reduces alcohol self-administration and the progressive ratio breakpoint, but not cue- or stress-induced reinstatement of alcohol-seeking behavior, in rats when administered intraperitoneally at a dose of 1 mg/kg. ML-154 (10 µg, i.c.v.) inhibits decreases in food intake induced by intracerebroventricular administration of NPS in rats.

WARNING This product is not for human or veterinary use.