Cayman Sor-C13 (Trifluoroacetate Salt); 5 Mg; ≥98%

Ruscogenin is a steroid sapogenin that has been found in O. japonicus with diverse biological activities.^,,,, It reduces adhesion of HL-60 cells to ECV304 cells induced by phorbol 12-myristate 13-acetate (PMA; Item No. ) with an IC₅₀ value of 7.76 nM and decreases peritoneal leukocyte migration induced by zymosan A (Item No. ) in mice when administered at a dose of 5 mg/kg. Oral administration of ruscogenin (12.5 mg/kg) inhibits ADP-induced platelet aggregation in rats. Ruscogenin prevents monocrotaline-induced increases in mean arterial pressure (MAP), expression of IL-1β and TNF in plasma and lung, and endothelial cell apoptosis in pulmonary arterioles in a rat model of pulmonary hypertension. It also reduces proteinuria and renal macrophage infiltration in a rat model of diabetes induced by streptozotocin (Item No. ) and decreases gene expression of inflammatory cytokines, dyslipidemia, and liver steatosis in a hamster model of high-fat diet-induced nonalcoholic steatohepatitis (NASH).^,

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