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Cayman Pbd-150; 100 Mg; 790663-33-1; ≥98%
List Price
$375.00
Your Price
$375.00
Cayman Pbd-150; 100 Mg; 790663-33-1; ≥98% - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-36112-100
MFG.PART:
36112-100
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
KRIBB3 is an Hsp27 and microtubule inhibitor that inhibits migration and invasion of MDA-MB-231 cells in vitro in an Hsp27-dependent manner., It inhibits protein kinase C (PKC) phosphorylation of Hsp27 but not phospholipase Cβ3, indicating KRIBB3 interaction with Hsp27 is preventing its phosphorylation. KRIBB3 (1-100 μM) inhibits growth of HCT116, HCT15, and MDA-MB-231 cells in an Hsp27-independent and concentration-dependent manner. It induces HCT116 cell cycle arrest in the G2/M phase via formation of the Mad2/p55CDC inhibitory complex and Bax activation of apoptosis. KRIBB3 also inhibits microtubule polymerization in HCT116 cells. In vivo, KRIBB3 (50-100 mg/kg) reduces tumor volume in an HCT116 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-ethyl-5-
CAS Number
129414-88-6
Molecular Formula
C19H19NO4
Formula Weight
325.4
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 25 mM
SMILES
OC1=CC(OC)=C(CC)C=C1C2=C(C3=CC=C(OC)C=C3)C=NO2
InChi Code
InChI=1S/C19H19NO4/c1-4-12-9-15(17(21)10-18(12)23-3)19-16(11-20-24-19)13-5-7-14(22-2)8-6-13/h5-11,21H,4H2,1-3H3
InChi Key
BNBHIGLOMVMJDB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-36112-100 |
|---|---|
| Featured | No |
| Supplier Part Number | 36112-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 790663-33-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |