Cayman Angiotensin A (Trifluoroacetate Salt); 25 Mg; ≥98%

Angiotensin A is an angiotensin II type 1 (AT₁) and AT₂ receptor agonist and active metabolite of the peptide hormone angiotensin II (Item No. 17150).¹ It is formed from angiotensin II via decarboxylation of the N-terminal aspartate residue. Angiotensin A binds to AT₁ and AT₂ receptors in HEK293 cells expressing the rat receptors (IC₅₀s = 0.29 and 0.12 nM, respectively, in radioligand binding assays) and induces calcium mobilization in vascular smooth muscle cells (VSMCs; EC₅₀ = 100 nM). It increases the perfusion pressure in isolated perfused rat kidney (EC₅₀ = 443 nM), an effect that can be reversed by the AT₁ antagonist EXP-3174 (losartan carboxylic acid; Item No. 15957). The ratio of angiotensin A to angiotensin II (Ang A/Ang II) in the plasma is increased in patients with end-stage renal failure and serum levels of angiotensin A are decreased in patients with pulmonary arterial hypertension.^1,2

WARNING This product is not for human or veterinary use.