Cayman Detyrosinated Α-Tubulin Rabbit Monoclonal Antibody, Size

Detyrosinated α-tubulin is a form of the cytoskeletal protein α-tubulin that has been post-translationally modified by the tubulin carboxypeptidases vasohibin 1 (VASH-1) and VASH-2, which remove the C-terminal tyrosine from α-tubulin.¹ Detyrosination of α-tubulin occurs in the cytosol and exposes two consecutive glutamate residues that can be further processed to form Δ2- or Δ3-tubulin. Detyrosinated α-tubulin monomers can be re-tyrosinated by tubulin tyrosine ligase and be incorporated into microtubules again. α-Tubulin detyrosination is associated with, but not sufficient for, increased stability of the microtubule and is involved in a variety of biological processes, including neuronal development, β-oxidation, mitosis, and cardiomyocyte contraction.^2,3,1,4 Increased levels of detyrosination are associated with tumor development in vitro, have been found in tumor tissue from patients with breast cancer, and are positively correlated with breast cancer aggressiveness.^5,6 Cayman’s Detyrosinated α-Tubulin Rabbit Monoclonal Antibody (Clone RM444) can be used for immunocytochemistry (ICC), immunofluorescence (IF), and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.