Cayman Sikvav (Acetate), 1g

(+)-JQ1 (Item No. ) binds to the acetyl-lysine recognition pocket of bromodomains 1 and 2 on BRD4 with K_d values of ~50 and 90 nM, respectively. This displaces BRD4 from nuclear chromatin in cells, inducing differentiation and growth arrest in midline carcinoma cells. CPI-203 is a primary amide analog of (+)-JQ1 which has shown superior bioavailability with oral or i.p. administration. It is comparable or superior to (+)-JQ1 in inhibiting BRD4 binding and action in vitro or in cells.^, CPI-203 arrests the growth of leukemic T cells in vitro (EC₅₀ = 91 nM) and rapidly suppresses leukemia burden in mice.

WARNING This product is not for human or veterinary use.