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Cayman Simvastatin Hydroxy Acid (Ammonium Salt), 50mg
List Price
$238.00
Your Price
$238.00
Cayman Simvastatin Hydroxy Acid (Ammonium Salt), 50mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-34883-50
MFG.PART:
34883-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
RG7388 is a non-imidazoline, selective MDM2 inhibitor that blocks the binding of MDM2 to p53 (IC50 = 30 nM). By inhibiting MDM2, RG7388 activates the p53 pathway in SJSA1 osteosarcoma cells and inhibits the growth of xenografts in nude mice., RG7388 is orally available and prolonged daily administration results in loss of MDM2 and p21 protein, growth inhibition, and apoptosis in SJSA1 xenograft tumors. Like other MDM2 inhibitors, RG7388 competitively inhibits multi-drug resistance protein 1 (MRP1) and reverse MRP1-mediated multidrug resistance in cancer cells in a p53-independent manner.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[[(2R,3S,
CAS Number
1229705-06-9
Synonyms
- Idasanutlin
- Ro 5503781
Molecular Formula
C31H29Cl2F2N3O4
Formula Weight
616.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: 100 mg/ml
- Ethanol: 8 mg/ml
- Water: < 1 mg/ml
λmax
220, 274, 302 nm
SMILES
O=C(NC1=C(OC)C=C(C(O)=O)C=C1)[C@@H]2N[C@@H](CC(C)(C)C)[C@@](C3=C(F)C=C(Cl)C=C3)(C#N)[C@H]2C4=CC=CC(Cl)=C4F
InChi Code
InChI=1S/C31H29Cl2F2N3O4/c1-30(2,3)14-24-31(15-36,19-10-9-17(32)13-21(19)34)25(18-6-5-7-20(33)26(18)35)27(38-24)28(39)37-22-11-8-16(29(40)41)12-23(22)42-4/h5-13,24-25,27,38H,14H2,1-4H3,(H,37,39)(H,40,41)/t24-,25-,27+,31?/m0/s1
InChi Key
TVTXCJFHQKSQQM-LZQLXLIZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34883-50 |
|---|---|
| Featured | No |
| Supplier Part Number | 34883-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 139893-43-9 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |