Cayman Incensole Acetate, 10mg

Sulindac sulfide is an active metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor sulindac (Item No, ).^, It inhibits both COX-1 and COX-2 (IC₅₀s = 1.9 and 1.21 µM, respectively), whereas the parent compound, sulindac, is much less effective (IC₅₀ = 58 µM for COX-2 and > 100 µM for COX-1). Sulindac sulfide also inhibits aldose reductase (IC₅₀ = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications. It increases the expression and activity of NAD(P)H quinone oxidoreductase 1. Sulindac sulfide inhibits colorectal cancer growth both in vitro and in vivo.

WARNING This product is not for human or veterinary use.