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Cayman Deltaline, 5mg
List Price
$116.00
Your Price
$116.00
Cayman Deltaline, 5mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-34612-5
MFG.PART:
34612-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
MI-2 is an inhibitor of the protein-protein interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 446 nM). It binds to menin (Kd = 158 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. MI-2 inhibits the growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL-AF9 (GI50 = 5 μM). It also inhibits the growth of MV4, KOPN-8, ML-2, and MonoMac6 MLL cells expressing MLL fusion proteins (GI50s = 9.5, 7.2, 8.7, and 18 μM, respectively), as well as induces hematopoietic differentiation.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[4-(4,5-
CAS Number
1271738-62-5
Molecular Formula
C18H25N5S2
Formula Weight
375.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 16 mg/ml
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 10 mg/ml
λmax
223, 287 nm
SMILES
CCCC(S1)=CC(C1=NC=N2)=C2N3CCN(C4=NCC(C)(C)S4)CC3
InChi Code
InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3
InChi Key
SRQYLNYQAPCPIR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34612-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 34612-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 6836-11-9 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |