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Cayman Spa70, 1mg
List Price
$32.00
Your Price
$32.00
Cayman Spa70, 1mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-34490-1
MFG.PART:
34490-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SPA70 is a pregnane X receptor (PXR) antagonist (IC50 = 0.51 µM).1 It is selective for PXR over 10 additional nuclear receptors at concentrations greater than 5 µM, as well as over a panel of 384 kinases at 10 µM. SPA70 (0.1-10 µM) inhibits PXR activation induced by rifampicin (Item No. 14423) in HEK293 cells expressing the human receptor. It also inhibits rifampicin-induced activity of the PXR target cytochrome P450 (CYP) isoform 3A4 (CYP3A4) in primary human hepatocytes. SPA70 (200 mg/kg) inhibits PXR agonist-induced CYP3A4-mediated metabolism of midazolam and paclitaxel (Item No. 10461) in human PXR transgenic (hPXR-tg) mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-(2,5-
CAS Number
931314-31-7
Synonyms
- Specific PXR Antagonist 70
Molecular Formula
C21H25N3O4S
Formula Weight
415.5
Purity
≥90%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- Chloroform: 10 mg/ml
λmax
234 nm
SMILES
COC1=CC(N2N=NC(S(C3=CC=C(C(C)(C)C)C=C3)(=O)=O)=C2C)=C(OC)C=C1
InChi Code
InChI=1S/C21H25N3O4S/c1-14-20(29(25,26)17-10-7-15(8-11-17)21(2,3)4)22-23-24(14)18-13-16(27-5)9-12-19(18)28-6/h7-13H,1-6H3
InChi Key
OIOPHIFJQXHPAF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34490-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 34490-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 931314-31-7 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |