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Cayman Dsr 6434; Qty- 5; Size-5 Mg
Product Description
Zotarolimus is a macrocyclic lactone immunosuppressant and a derivative of rapamycin (Item No. )., It binds to FKBP prolyl isomerase 1A (FKBP12; IC50 = 2.57 nM) and inhibits proliferation of human peripheral blood mononuclear cells (PBMCs), rat splenocytes, and human coronary artery smooth muscle cells (IC50s = 7, 1,337, and 0.8 nM, respectively). Zotarolimus has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s = 1.2 and 1,465 nM, respectively). It also reduces symptom severity in a rat model of experimental autoimmune encephalomyelitis (EAE; ED50 = 1.17 mg/kg per day) and delays cardiac allograft rejection in rats (ED50 = 3.71 mg/kg per day). Zotarolimus inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 µg/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis. Formulations containing zotarolimus have been used in drug-eluting stents in the prevention of restenosis following stent placement.
WARNING This product is not for human or veterinary use.
Technical Information
- A-179578
- ABT-578
- DMF: 15mg/mL
- DMSO: 15mg/mL
- Ethanol: 20mg/mL
- Ethanol:PBS (pH 7.2) (1:3): 0.25mg/mL
Shipping & Storage Information
| SKU | CAYM-34331-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 34331-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1059070-10-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |