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Cayman Mauritianin; Qty- 5; Size-5 Mg
List Price
$306.00
Your Price
$306.00
Cayman Mauritianin; Qty- 5; Size-5 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-34326-5
MFG.PART:
34326-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Rostafuroxin potently inhibits binding of endogenous ouabain to the Na+/K+ ATPase (IC50 = 1.7 µM) through the Src-epidermal growth factor receptor (EGFR)-dependent signaling pathway. This blocks the ouabain-dependent increase in Na+/K+ ATPase activity. In cultured renal cells where the Na+/K+ ATPase is upregulated or has increased activity, rostafuroxin normalizes mRNA levels and Na+/K+ ATPase activity. At very low doses (1 and 10 µg/kg for 5-6 weeks) in Milan-hypertensive rats, it decreased the development of hypertension. In a Phase II clinical study, rostafuroxin did not reduce blood pressure in human patients at doses of 0.05-5.0 mg/d.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3β,5β,14β)- 21,23-epoxy- 24-norchola- 20,22-diene- 3,14,17-triol
CAS Number
156722-18-8
Synonyms
- PST 2238
Molecular Formula
C23H34O4
Formula Weight
374.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 2 mg/ml
- DMSO: 0.1 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
212 nm
SMILES
O[C@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@]3(O)CC[C@]4(O)C5=COC=C5)([H])C1
InChi Code
InChI=1S/C23H34O4/c1-20-8-5-17(24)13-15(20)3-4-19-18(20)6-9-21(2)22(25,10-11-23(19,21)26)16-7-12-27-14-16/h7,12,14-15,17-19,24-26H,3-6,8-11,13H2,1-2H3/t15-,17+,18+,19-,20+,21-,22+,23+/m1/s1
InChi Key
AEAPORIZZWBIEX-DTBDINHYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34326-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 34326-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 109008-28-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |