Cayman 1-1(Z)-Hexadecenyl-2-Arachidonoyl-Sn-Glycero-3-Pc; 1 Mg; 84460-45-7; ≥95%

Cross-talk between lipoxygenase (LO) and cyclooxygenase (COX) pathways has been observed in human osteoarthritic synovial explants which creates an arachidonic acid shunting phenomenon, stimulating interleukin-1β (IL-1β) synthesis. Licofelone is a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LO) pathways, that decreases levels of prostaglandin E₂, leukotriene B₄, and lipoxins and prevents lipopolysaccharide-stimulated IL-1β expression. The IC₅₀ values for inhibition of human thrombocyte COX and human 5-LO are 0.16 µM and 0.23 µM, respectively. Unlike other non-steroidal anti-inflammatory drugs, licofelone causes little or no damage to the gastric mucosa in rabbit parietal cells. This is presumably the result of licofelone’s affects on acid-secretory mechanisms, mediated by the inhibition of 5-LO activity.

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