Cayman Gossypin; Qty- 100; Size-100 Mg

Gossypin is a flavonoid glycoside originally isolated from H. vitifolius that has diverse biological activities.^1,2,3,4,5 It inhibits RANKL-induced osteoclastogenesis in RAW 264.7 cells when used at a concentration of 5 µM.¹ Gossypin inhibits Aurora B kinase (IC₅₀ = 11.07 µM in a cell-free assay using the human enzyme), as well as Aurora A kinase and p90 ribosomal S6 kinase 2 (RSK2) at 20 µM.^2,3 It induces cell cycle arrest at the G₂/M phase and apoptosis in HGC-27 gastric cancer cells.³ Gossypin decreases lactate dehydrogenase (LDH) release induced by the glutathione-depleting agent D,L-buthionine (S,R)-sulfoximine (Item No. 23691) in primary rat cortical cells (IC₅₀ = 7.4 µg/ml).⁴ It reduces acetic acid-induced writhing in mice, an effect that can be reversed by the opioid antagonist naloxone, in a dose-dependent manner.⁵

WARNING This product is not for human or veterinary use.