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Cayman Gossypin; Qty- 100; Size-100 Mg
Product Description
Gossypin is a flavonoid glycoside originally isolated from H. vitifolius that has diverse biological activities.1,2,3,4,5 It inhibits RANKL-induced osteoclastogenesis in RAW 264.7 cells when used at a concentration of 5 µM.1 Gossypin inhibits Aurora B kinase (IC50 = 11.07 µM in a cell-free assay using the human enzyme), as well as Aurora A kinase and p90 ribosomal S6 kinase 2 (RSK2) at 20 µM.2,3 It induces cell cycle arrest at the G2/M phase and apoptosis in HGC-27 gastric cancer cells.3 Gossypin decreases lactate dehydrogenase (LDH) release induced by the glutathione-depleting agent D,L-buthionine (S,R)-sulfoximine (Item No. 23691) in primary rat cortical cells (IC50 = 7.4 µg/ml).4 It reduces acetic acid-induced writhing in mice, an effect that can be reversed by the opioid antagonist naloxone, in a dose-dependent manner.5
WARNING This product is not for human or veterinary use.
Technical Information
- Gossypetin-8-O-glucoside
- DMF: 30 mg/ml
- DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml
- DMSO: 25 mg/ml
Shipping & Storage Information
| SKU | CAYM-34142-100 |
|---|---|
| Featured | No |
| Supplier Part Number | 34142-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 652-78-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |