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Cayman Isoscopoletin; Qty- 25; Size-25 Mg
List Price
$113.00
Your Price
$113.00
Cayman Isoscopoletin; Qty- 25; Size-25 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-34117-25
MFG.PART:
34117-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Palovarotene an orally bioavailable retinoic acid receptor γ (RARγ) agonist. It increases retinoic acid response element (RARE) activity and decreases NF-κB activity induced by IL-1β in primary mouse stromal cells in reporter assays when used at a concentration of 60 nM. Palovarotene (10 nM) inhibits activin A-induced chondrogenic and osteogenic differentiation of mouse fibro/adipogenic progenitors (FAPs) expressing a mutated form of human activin A receptor type I (ACVR1R206H). It inhibits heterotopic ossification and preserves limb movement and growth in a ACVR1R206H fibrodysplasia ossificans progressiva (FOP) mouse model. Palovarotene (1 mg/kg per day for 14 days) decreases heterotopic ossification by 50 to 60% in a rat model of traumatic blast injury.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(1E)-2-
CAS Number
410528-02-8
Synonyms
- Ro 3300074
Molecular Formula
C27H30N2O2
Formula Weight
414.5
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 25 mg/ml
- DMSO: 20 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
- Ethanol: 3 mg/ml
λmax
321 nm
SMILES
CC1(C)CCC(C)(C)C2=C1C=C(CN3C=CC=N3)C(/C=C/C4=CC=C(C(O)=O)C=C4)=C2
InChi Code
InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+
InChi Key
YTFHCXIPDIHOIA-DHZHZOJOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-34117-25 |
|---|---|
| Featured | No |
| Supplier Part Number | 34117-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 776-86-3 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |