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Cayman Deoxymethoxetamine (Hydrochloride); Qty- 5; Size-5 Mg
List Price
$356.00
Your Price
$356.00
Cayman Deoxymethoxetamine (Hydrochloride); Qty- 5; Size-5 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-33962-5
MFG.PART:
33962-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC50s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC50 = 3,080 nM). JH-II-127 (0.1-0.3 µM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[4-[[5-chloro- 4-(methylamino)- 7H-pyrrolo[2,3- d]pyrimidin-2- yl]amino]-3- methoxyphenyl]-4- morpholinyl- methanone
CAS Number
1700693-08-8
Molecular Formula
C19H21ClN6O3
Formula Weight
416.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- Ethanol: 2 mg/ml
λmax
268, 321 nm
SMILES
O=C(C1=CC(OC)=C(NC2=NC(NC)=C(C(Cl)=CN3)C3=N2)C=C1)N4CCOCC4
InChi Code
InChI=1S/C19H21ClN6O3/c1-21-16-15-12(20)10-22-17(15)25-19(24-16)23-13-4-3-11(9-14(13)28-2)18(27)26-5-7-29-8-6-26/h3-4,9-10H,5-8H2,1-2H3,(H3,21,22,23,24,25)
InChi Key
HUEKBQXFNHWTQQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-33962-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 33962-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |