Cayman Fr900359, 250ug

Tropisetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 0.8 nM for the mouse receptor). It is selective for 5-HT₃ over the 5-HT₄ receptor subtype (K_i = 156 nM for the porcine receptor). Tropisetron is also an antagonist of the α9 nicotinic acetylcholine receptor (nAChR; IC₅₀ = 166 nM for the rat receptor) and a partial agonist of the α7 nAChR (K_i = 6.9 nM for the rat receptor).^, It enhances glycine-induced potentiation of homomeric α1 but not homomeric α2 glycine receptors when used at a concentration of 10 µM. Tropisetron (0.1 nM) blocks 5-HT-induced depolarizations in isolated rabbit nodose ganglia. It exhibits anti-emetic effects in a ferret model of emesis induced by cisplatin (Item No. ) when administered at a dose of 1 mg/kg. Formulations containing tropisetron have been used in the treatment of nausea and vomiting associated with chemotherapy.

WARNING This product is not for human or veterinary use.