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Cayman Pf-998425, 4--2-(Trifluoromet
List Price
$178.00
Your Price
$178.00
Cayman Pf-998425, 4-[(1r,2r)-2-Hydroxycyclohexyl]-2-(Trifluoromethyl)-Benzonitrile, 10 Mg - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-31442-10
MFG.PART:
31442-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
TB5 is a potent and selective monoamine oxidase B (MAO-B) inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively. It interacts with the catalytic site of human MAO-B in a competitive manner. In an enzyme assay, MAO-B activity increases from 37% to 97% following inhibitor washout, indicating TB5 binding is reversible. TB5 also demonstrates permeability in a parallel artificial membrane permeation assay (PAMPA), a model for the blood-brain barrier, and has minimal cytotoxicity (>84% cell viability) in HepG2 cells at a concentrations up to 25 μM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2E)-1-(5-
CAS Number
948841-07-4
Molecular Formula
C15H14BrNOS
Formula Weight
336.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 33 mg/ml
- DMSO: 33 mg/ml
- Ethanol: 1 mg/ml
λmax
436 nm
SMILES
CN(C)C1=CC=C(/C=C/C(C2=CC=C(Br)S2)=O)C=C1
InChi Code
InChI=1S/C15H14BrNOS/c1-17(2)12-6-3-11(4-7-12)5-8-13(18)14-9-10-15(16)19-14/h3-10H,1-2H3/b8-5+
InChi Key
PTLDLBSWTKNYCY-VMPITWQZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-31442-10 |
|---|---|
| Featured | No |
| Supplier Part Number | 31442-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1076225-27-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |