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Cayman Acumapimod; Purity- Greater Than Or Equal To 98%; Size- 5
List Price
$145.00
Your Price
$145.00
Cayman Acumapimod; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25832-5
MFG.PART:
25832-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Risdiplam is a survival of motor neuron-2 (SMN2) splicing modifier. It enhances SMN2 splicing (EC1.5x = 40 nM) and increases SMN protein levels (EC1.5x = 163 nM) in cellular assays. Risdiplam (3 mg/kg) increases brain and quadricep muscle SMN protein levels in the adult C/C-allele mouse model of mild spinal muscular atrophy (SMA) and the SMND7 neonate mouse model of severe SMA. It also increases the number of vesicular glutamate transporter 1 (vGLUT1) proprioceptive inputs on motor neurons, the number of L3 to L5 spinal motor neurons, the percentage of fully innervated neuromuscular junctions (NMJs), and the size of the extensor digitorum longus muscles in adult SMND7 mice. Formulations containing risdiplam have been used in the treatment of spinal muscular atrophy.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-(4,7-diaza
CAS Number
1825352-65-5
Synonyms
- RG-7916
- RO7034067
Molecular Formula
C22H23N7O
Formula Weight
401.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- Chloroform: 10 mg/ml
λmax
255, 287, 404 nm
SMILES
O=C1C=C(C(C=C2C)=NN3C2=NC(C)=C3)N=C4N1C=C(N5CCNC6(CC6)C5)C=C4
InChi Code
InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3
InChi Key
ASKZRYGFUPSJPN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25832-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 25832-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 836683-15-9 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |