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Cayman 1-Palmitoleoyl Glycerol; Purity- Greater Than Or Equal To
List Price
$71.40
Your Price
$71.40
Cayman 1-Palmitoleoyl Glycerol; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25697-25
MFG.PART:
25697-25
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Artesunate is a derivative of artemisinin (Item No. ) that is active against P. falciparum in vitro (IC50 = 1.28 nM). It is an iron(II) oxide-reactive endoperoxide that generates reactive oxygen species (ROS) upon cleavage of its endoperoxide bridge. It inhibits the activity of the P. falciparum EXP1, a glutathione S-transferase (GST) that degrades hematin, with an IC50 value of 2.05 nM. Artesunate inhibits proliferation of germinal center B cells in vitro and prevents development of arthritis via inhibition of germinal center formation and autoantibody production in the K/BxN mouse model of rheumatoid arthritis when administered at a dose of 100 mg/kg twice per day. It also inhibits alveolitis and pulmonary fibrosis induced by bleomycin (Item No. ) in rats. Artesunate increases the activity of GST in mice infected with P. berghei compared to uninfected and infected control animals.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
butanedioic acid, 1-[(3R,5aS,
CAS Number
88495-63-0
Synonyms
- Artesunic Acid
- NSC 712571
- WR 256283
Molecular Formula
C19H28O8
Formula Weight
384.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 11 mg/ml
- DMSO: 14 mg/ml
- Ethanol: 20 mg/ml
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
[H][C@]12[C@@H](C)[C@H](OC(CCC(O)=O)=O)O[C@@]3([H])[C@@]1(OO4)[C@](CC[C@]4(C)O3)([H])[C@H](C)CC2
InChi Code
InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1
InChi Key
FIHJKUPKCHIPAT-AHIGJZGOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25697-25 |
|---|---|
| Featured | No |
| Supplier Part Number | 25697-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Sweden |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 37515-61-0 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |