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Cayman Sch 39166 (Hydrobromide); Purity- Greater Than Or Equal To
List Price
$40.00
Your Price
$40.00
Cayman Sch 39166 (Hydrobromide); Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-25331-1
MFG.PART:
25331-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Polo-like kinases (Plks) are serine/threonine kinases with key roles in cell cycling. TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2, and Plk3, respectively., It exhibits greater than 20-fold selectivity for Plk1 over FAK, MLCK, and the tyrosine protein kinase Fes, and has minimal activity against a panel of 282 other kinases., It inhibits the proliferation of various cancer cell lines, including MDR1-expressing tumors, and also prevents tumor growth in several human cancer cell xenograft models, including a disseminated model of AML- and MDR1-expressing hematological tumors.,
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(9-cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)-benzamide
CAS Number
1137868-52-0
Molecular Formula
C27H34F3N7O3
Formula Weight
561.6
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/ml
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 12 mg/ml
λmax
280, 330 nm
SMILES
CN1CCC(NC(C2=CC(OC)=C(NC3=NC=C(N(C)C(C(F)(F)CN4C5CCCC5)=O)C4=N3)C=C2F)=O)CC1
InChi Code
InChI=1S/C27H34F3N7O3/c1-35-10-8-16(9-11-35)32-24(38)18-12-22(40-3)20(13-19(18)28)33-26-31-14-21-23(34-26)37(17-6-4-5-7-17)15-27(29,30)25(39)36(21)2/h12-14,16-17H,4-11,15H2,1-3H3,(H,32,38)(H,31,33,34)
InChi Key
GWRSATNRNFYMDI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-25331-1 |
|---|---|
| Featured | No |
| Supplier Part Number | 25331-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 1227675-51-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |