Cayman Zotepine; Purity- Greater Than Or Equal To 98%; Size- 100

Zotepine is an atypical antipsychotic.¹ It is a dopamine D₂ and D₃ receptor antagonist (K_is = 5.37 and 6.45 nm, respectively) that reverses dopamine inhibition of forskolin-stimulated cAMP production in CHO cells expressing human D₂ and D₃ receptors. In vivo, zotepine inhibits head twitches induced by 5-hydroxy-L-tryptophan (Item No. 20539), a behavior mediated by the serotonin (5-HT) receptor subtype 5-HT₂, in mice (ED₅₀ = 0.13 mg/kg).² It acts as an α₂-adrenergic receptor (α₂-AR) antagonist, reducing the hind limb flexor reflex stimulated by clonidine (Item No. 15949) in rats. Zotepine blocks gnawing behavior and body turning induced by apomorphine (Item No. 16094) and methamphetamine in rats.³ It also induces catalepsy and inhibits apomorphine-induced vomiting in dogs. Formulations containing zotepine have been used in the treatment of schizophrenia and acute mania.

WARNING This product is not for human or veterinary use.