Cayman Bethanechol (Chloride); Purity- Greater Than Or Equal To 9

Bethanechol is an agonist of muscarinic acetylcholine receptors with IC₅₀ values of 1,837, 25, 631, 317, and 393 µM for M_1-5, respectively, in a radioligand binding assay using CHO cells expressing the human receptors.¹ It inhibits M₂-mediated increases in cyclic AMP induced by isoproterenol (Item No. 15592) in isolated guinea pig small intestine (IC₅₀ = 127 µM).² Bethanechol increases basal tone of isolated porcine intravesical ureter (EC₅₀ = 4.27 µM).³ It also induces fluid secretion in the ileum, duodenum, and jejunum of anesthetized rats when administered at a dose of 60 µg/kg.⁴ Formulations containing bethanechol have been used to increase urination and improve smooth muscle tone in the gastrointestinal tract.

WARNING This product is not for human or veterinary use.