Cayman Halcinonide; Purity- Greater Than Or Equal To 98%; Size- 1

YM-976 is a phosphodiesterase 4 (PDE4) inhibitor (IC₅₀ = 2.2 nM for the human peripheral leukocyte enzyme). It is selective for PDE4 over PDE1, -2, -3, and -5 (IC₅₀s = >3 µM for all). YM-976 inhibits LPS-induced TNF-α production in human peripheral blood mononuclear cells (PBMCs). In vivo, YM-976 inhibits carrageenan-induced pleural cavity cell infiltration in a rat model of pleurisy (ED₃₀ = 9.1 mg/kg). It inhibits antigen-induced lung eosinophil infiltration in rats, mice, and ferrets (ED₅₀s = 1.7, 5.8, and 1.2 mg/kg, respectively) and does not induce emesis in ferrets when administered at doses up to 10 mg/kg. YM-976 reduces ovalbumin-induced bronchoconstriction, as well as airway plasma leakage, eosinophil infiltration, and hyperreactivity in a guinea pig model of asthma (ED₅₀s = 7.3, 5.7, 1, and 0.52 mg/kg, respectively). It also reduces citric acid-induced cough in guinea pigs.

WARNING This product is not for human or veterinary use.