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Cayman Ym-90709; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
List Price
$93.00
Your Price
$93.00
Cayman Ym-90709; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-23448-5
MFG.PART:
23448-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
ABT-639 is a T-type calcium channel blocker. It inhibits inactivated-state Cav3.2 channels with an IC50 value of 2.3 μM and inactivated-state Cav3.1 and Cav3.3 channels by 50 and 39%, respectively, when used at a concentration of 10 μM. ABT-639 selectively inhibits inactivated-state T-type calcium currents over resting-state currents in rat dorsal root ganglion (DRG) neurons (IC50s = 7.6 and >30 μM, respectively). It reverses the hind limb grip force deficit in a rat model of osteoarthritic pain induced by monoiodoacetic acid (MIA; ED50 = 2 mg/kg). ABT-639 also increases the paw withdrawal threshold in rat spinal nerve ligation (SNL) and chronic constriction injury (CCI) models of neuropathic pain in a dose-dependent manner and attenuates cold allodynia in the CCI rat model when administered at doses greater than or equal to 3 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-chloro-2-
CAS Number
1235560-28-7
Molecular Formula
C20H20ClF2N3O3S
Formula Weight
455.9
Purity
≥98%
Formulation
A solid
Solubility
- DMF: 14 mg/ml
- DMF:PBS (pH 7.2) (1:20): 0.04 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 0.5 mg/ml
SMILES
FC1=C(S(NC2=CC=CC=C2F)(=O)=O)C=C(C(N3CCN(CCC4)[C@@]4([H])C3)=O)C(Cl)=C1
InChi Code
InChI=1S/C20H20ClF2N3O3S/c21-15-11-17(23)19(30(28,29)24-18-6-2-1-5-16(18)22)10-14(15)20(27)26-9-8-25-7-3-4-13(25)12-26/h1-2,5-6,10-11,13,24H,3-4,7-9,12H2/t13-/m1/s1
InChi Key
AGPIHNZOZNKRGT-CYBMUJFWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-23448-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 23448-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 163769-88-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |