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Cayman 2-Deoxycytidine 5-Diphosphate (Sodium Salt Hydrate); Pur
List Price
$44.00
Your Price
$44.00
Cayman 2-Deoxycytidine 5-Diphosphate (Sodium Salt Hydrate); Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-22982-5
MFG.PART:
22982-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptors putative ligand binding domain without exerting significant effects on DNA binding. It inhibits the expression of IL-17 (at 0.5 µM) in naïve CD4+ T cells activated under Th17-cell-polarizing conditions and affects the broader RORγt-dependent gene network, inhibiting the development and pathogenic function of Th17 cells. GSK805 significantly reduces the severity of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, when given orally to the hosts at 10 mg/kg daily beginning at the time of disease induction.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[2,6-dichloro-
CAS Number
1426802-50-7
Molecular Formula
C23H18Cl2F3NO4S
Formula Weight
532.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 3 mg/ml
- DMSO: 5 mg/ml
- DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
λmax
221, 256 nm
SMILES
ClC1=CC(NC(CC2=CC=C(S(CC)(=O)=O)C=C2)=O)=CC(Cl)=C1C3=C(OC(F)(F)F)C=CC=C3
InChi Code
InChI=1S/C23H18Cl2F3NO4S/c1-2-34(31,32)16-9-7-14(8-10-16)11-21(30)29-15-12-18(24)22(19(25)13-15)17-5-3-4-6-20(17)33-23(26,27)28/h3-10,12-13H,2,11H2,1H3,(H,29,30)
InChi Key
CEICQMBWAQAIQX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-22982-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 22982-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| CAS Number | 151151-32-5 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |