Cayman Dolasetron; Purity- Greater Than Or Equal To 98%; Size- 50

Dolasetron is an antagonist of the serotonin (5-HT) receptor subtype 5-HT₃ (K_i = 20 nM).¹ It is selective for 5-HT₃ receptors over 5-HT_1A, 5-HT_1B, 5-HT₂, dopamine D₂, α₁-, α₂-, β-adrenergic, M_1-5 muscarinic acetylcholine, and neurokinin-1 (NK₁) receptors (IC₅₀s = >10 µM for all).² Dolasetron inhibits 5-HT-induced membrane currents in NG 108-15 cells (IC₅₀ = 3.8 nM).¹ It increases the latency to emesis and reduces the number of vomiting and retching episodes induced by cisplatin (Item No. 13119) in ferrets when administered at doses of 0.5 or 2 mg/kg.² Formulations containing dolasetron have been used in the prevention of postoperative or chemotherapy-induced nausea.

WARNING This product is not for human or veterinary use.