Cayman Ipsapirone; Purity- Greater Than Or Equal To 98%; Size- 5

Ipsapirone is a partial agonist of the serotonin (5-HT) receptor 5-HT_1A (K_i = 10 nM in hippocampal membranes).¹ It reduces 5-HT release in rat ventral hippocampus in vivo.² Low doses of ipsapirone decrease, while high doses increase, extracellular dopamine release in murine nucleus accumbens.³ Extracellular dopamine levels in murine striatum increase following administration of ipsapirone at concentrations >0.1 mg/kg. Ipsapirone has anxiolytic effects in vivo, inhibiting foot shock-induced aggression and passive avoidance behavior in rats (ED₅₀s = 2.2 and 0.5 mg/kg, respectively).⁴ Formulations containing ipsapirone have been used to treat depression and borderline personality disorder.⁵

WARNING This product is not for human or veterinary use.