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Cayman Lxr-623; Purity- Greater Than Or Equal To 98%; Size- 5 Mg
List Price
$105.00
Your Price
$105.00
Cayman Lxr-623; Purity- Greater Than Or Equal To 98%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21117-5
MFG.PART:
21117-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Cancer cell survival appears partly dependent on antioxidative enzymes, whose expression is regulated by the Keap1-Nrf2 pathway, to quench potentially toxic reactive oxygen species generated by their metastatic transformation. AEM1 is an inhibitor of gene expression induced by nuclear erythroid 2-related factor 2 (Nrf2). It reduces Nrf2-dependent expression of the genes encoding superoxide dismutase 1 (SOD1), heme oxygenase 1 (HO-1), thioredoxin (Trx), glutamate-cysteine ligase (GCLM), and glutathione peroxidase 2 (GPX2), as well as decreases glutathione (GSH) content in A549 cells when used at 5 µM. AEM1 enhances tert-butyl hydroperoxide-induced A549 cell death. In vivo, AEM1 (50 mg/kg) reduces tumor volume in an A549 mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(1,3-benzodioxol-
CAS Number
1030123-90-0
Molecular Formula
C20H14FN3O2S
Formula Weight
379.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 0.25 mg/mL
λmax
283 nm
SMILES
FC(C=C1)=CC=C1C2=CSC3=C2C(NCC4=CC=C(OCO5)C5=C4)=NC=N3
InChi Code
InChI=1S/C20H14FN3O2S/c21-14-4-2-13(3-5-14)15-9-27-20-18(15)19(23-10-24-20)22-8-12-1-6-16-17(7-12)26-11-25-16/h1-7,9-10H,8,11H2,(H,22,23,24)
InChi Key
QGYLTGSHWIGJJD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21117-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 21117-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer Name | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | Y |
| CAS Number | 875787-07-8 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |