Cayman Dc4 Crosslinker Purity 98% 5 Mg

α-Hydroxyglutaric acid (2-HG; Item No. ) is normally metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases. Mutations in these enzymes cause 2-hydroxyglutaric aciduria, a neurometabolic disorder.^,, Recent studies have found that mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2, typically associated with certain cancers, can cause these enzymes to convert isocitrate to 2-HG, rather than α-ketoglutarate.^, 2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including lysine demethylases and DNA hydroxylases.^,, (2S)-Octyl-α-hydroxyglutarate is a cell-permeable derivative of the L-isomer of 2-HG.

WARNING This product is not for human or veterinary use.