Cayman Prostaglandin D2 Serinol Amide; Purity- Greater Than Or Eq

Maprotiline-d₃ is intended for use as an internal standard for the quantification of maprotiline (Item No. ) by GC- or LC-MS. Maprotiline is a tricyclic antidepressant.^, It binds to the norepinephrine transporter (NET; K_d = 11 nM) and is selective for NET over the serotonin (5-HT) and dopamine transporters (K_ds = 5,800 and 1,000 nM, respectively). Maprotiline also binds to the 5-HT receptor subtype 5-HT_2A (K_i = 51 nM), as well as histamine H₁, muscarinic acetylcholine, α₁-adrenergic, and dopamine D₂ receptors (K_ds = 2, 570, 90, and 350 nM, respectively). In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline (20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. ). Formulations containing maprotiline have been used in the treatment of depression and anxiety. This product is also available as an analytical reference material (Item Nos. | ).

WARNING This product is not for human or veterinary use.