Cayman Bay U3405; Purity- Greater Than Or Equal To 98%; Size- 10

Ramatroban is a dual TP and DP₂/CRTH₂ receptor antagonist (K_is = 4.5 and 4.3 nM for the human receptors, respectively).¹ It is selective for these receptors over the prostaglandin E₂ (PGE₂) receptor subtypes EP₁ and EP₂, as well as the FP and IP receptors, at 1 µM.² Ramatroban inhibits contractions induced by U-46619 (Item No. 16450) or PGD₂ (Item No. 12010) in isolated guinea pig tracheal rings (pA₂s = 8.7 and 8.6, respectively). It also reduces PGD₂-induced migration of isolated human eosinophils when used at concentrations of 1, 10, and 100 nM.³ Ramatroban (5 mg/kg) inhibits ovalbumin-induced airway eosinophil infiltration and mucus cell hyperplasia in an ovalbumin-sensitized mouse model of asthma.⁴ Formulations containing ramatroban have been used in the treatment of allergic rhinitis.

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