Cayman Cay10452; Purity- Greater Than Or Equal To 98%; Size- 25 M

Name: Cayman Cay10452; Purity- Greater Than Or Equal To 98%; Size- 25 M
SKU: CAYM-10075-25
Price: 357.00 USD

List Price $357.00 Your Price $357.00

Cayman Cay10452; Purity- Greater Than Or Equal To 98%; Size- 25 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-10075-25

MFG.PART: 10075-25

UNSPSC: 12352200

Manufacturer: Cayman

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Description

Product Description

Urocortin III is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF, urocortin (Item No. ), urocortin II (Item No. ), frog sauvagine, and piscine urotensin I. Human urocortin III shares 90, 40, 37, and 21% identity to mouse urocortin III (Item Nos. | ), mouse urocortin II (Item No. ), human urocortin (Item No. ), and mouse urocortin, respectively. Urocortin III selectively binds to type 2 CRF receptors (K_is = 21.7, 13.5, and >100 nM for rat CRF_2α, rat CRF_2β, and human CRF₁, respectively). It stimulates cAMP production in CHO cells expressing rat CRF_2α and mouse CRF_2β (EC₅₀s = 0.16 and 0.12 nM, respectively) as well as cultured anterior pituitary cells expressing endogenous CRF_2β. Urocortin III is co-released with insulin to potentiate glucose-stimulated somatostatin release in vitro in human pancreatic β-cells. In vivo, urocortin III reduces food intake in a dose- and time-dependent manner in mice with a minimum effective dose (MED) of 0.3 nmol/animal. It increases swimming time in a forced swim test in mice, indicating antidepressant-like activity.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

L-phenylalanyl-L-threonyl-L-leucyl-L-seryl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-threonyl-L-asparaginyl-L-isoleucyl-L-methionyl-L-asparaginyl-L-leucyl-L-leucyl-L-phenylalanyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-asparaginyl-L-leucyl-L-arginyl-L-alanyl-L-glutaminyl-L-alanyl-L-alanyl-L-alanyl-L-asparaginyl-L-alanyl-L-histidyl-L-leucyl-L-methionyl-L-alanyl-L-glutaminyl-L-isoleucinamide, 2,2,2-trifluoroacetate

CAS Number

357952-09-1

Molecular Formula

C₁₈₅H₃₀₇N₅₃O₅₀S₂ • XCF₃COOH

Formula Weight

4137.9

Purity

≥95%

Formulation

A lyophilized powder

Solubility

DMSO: 1 mg/ml

SMILES

NC([C@@]([C@H](CC)C)([H])NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC([C@@]([C@H](CC)C)([H])NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@@H]1CCCN1C([C@H](C(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@@]([C@@H](C)O)([H])NC([C@@H](N[H])CC2=CC=CC=C2)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)C)=O)=O)C)=O)=O)=O)=O)=O)C)=O)=O)C)=O)C)=O)C)=O)=O)C)=O)CC4=CN=CN4)=O)=O)CCSC)=O)C)=O)=O)=O.O=C(O)C(F)(F)F

InChi Code

InChI=1S/C185H307N53O50S2.C2HF3O2/c1-33-93(18)142(147(196)251)233-163(267)114(57-59-134(190)243)213-152(256)101(26)207-160(264)115(60-66-289-31)215-166(270)118(69-87(6)7)220-172(276)124(76-108-83-199-85-201-108)217-155(259)102(27)208-164(268)125(77-135(191)244)218-154(258)98(23)203-148(252)96(21)202-149(253)97(22)204-159(263)113(56-58-133(189)242)212-151(255)100(25)206-158(262)112(54-46-64-200-185(197)198)214-165(269)117(68-86(4)5)221-173(277)126(78-136(192)245)225-161(265)111(53-43-45-63-187)211-150(254)99(24)205-157(261)110(52-42-44-62-186)210-153(257)103(28)209-180(284)143(94(19)34-2)234-175(279)128(80-138(194)247)227-171(275)123(75-107-50-40-37-41-51-107)224-168(272)120(71-89(10)11)219-167(271)119(70-88(8)9)222-174(278)127(79-137(193)246)226-162(266)116(61-67-290-32)216-181(285)144(95(20)35-3)235-176(280)129(81-139(195)248)230-183(287)146(105(30)241)237-179(283)132-55-47-65-238(132)184(288)141(92(16)17)232-177(281)130(82-140(249)250)228-169(273)121(72-90(12)13)223-178(282)131(84-239)231-170(274)122(73-91(14)15)229-182(286)145(104(29)240)236-156(260)109(188)74-106-48-38-36-39-49-106;3-2(4,5)1(6)7/h36-41,48-51,83,85-105,109-132,141-146,239-241H,33-35,42-47,52-82,84,186-188H2,1-32H3,(H2,189,242)(H2,190,243)(H2,191,244)(H2,192,245)(H2,193,246)(H2,194,247)(H2,195,248)(H2,196,251)(H,199,201)(H,202,253)(H,203,252)(H,204,263)(H,205,261)(H,206,262)(H,207,264)(H,208,268)(H,209,284)(H,210,257)(H,211,254)(H,212,255)(H,213,256)(H,214,269)(H,215,270)(H,216,285)(H,217,259)(H,218,258)(H,219,271)(H,220,276)(H,221,277)(H,222,278)(H,223,282)(H,224,272)(H,225,265)(H,226,266)(H,227,275)(H,228,273)(H,229,286)(H,230,287)(H,231,274)(H,232,281)(H,233,267)(H,234,279)(H,235,280)(H,236,260)(H,237,283)(H,249,250)(H4,197,198,200);(H,6,7)/t93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104+,105+,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,141-,142-,143-,144-,145-,146-;/m0./s1

InChi Key

ZMELYLRCZAEWRR-WABNFCLFSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-10075-25
Featured	No
Supplier Part Number	10075-25
UM	EA
UNSPSC	12352200
Manufacturer Name	Cayman
MSDS URL	Click here
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	United States
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	2
Hazardous	N
CAS Number	170569-87-6
Energy Star	No
Green	No
ACT Ecolabel	No
Controlled	N

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NETA PART NO.	Quantity

Cayman Cay10452; Purity- Greater Than Or Equal To 98%; Size- 25 M

Product Description

Technical Information

Shipping & Storage Information

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