Vector Biolabs, a Fortis LS Co. ADENOVIRUS-CBR

Vector Biolabs Adenomatous polyposis coli gene (APC) is a tumor suppressor gene located on chromosome 5q2. It is inactivated in most colorectal tumors. APC is a cytoplasmic protein that can bind to and promote the degradation of b-catenin. In most colorectal tumors, APC is inactivated. This increases the interaction between b-catenin and Tcf family of transcription factors, leading to increase transcription of genes such as c-Myc.This adenovirus contains APC mini-me fragment.Shih IM., et al., Cancer Res. 2000 Mar 15;60(6):1671-6. - FLSVL (Additional S&H Or Hazmat Fees May Apply)