Vector Biolabs, a Fortis LS Co. ADENOVIRUS-CMV-NIK

Vector Biolabs NFkB-Inducing Kinase (NIK)The NFkB transcription factor can be activated by several cytokines including TNF and IL-1. The TNF receptor activates NFkB through the Traf2 adapter protein , whereas the IL-1 receptor activates NFkB in a pathway involving Traf6 . Both Traf2 and Traf6 have been shown to interact with a serine/threonine kinase designated NFkB inducing kinase (NIK), which appears to participate in the NFkB signaling cascades triggered by both TNF and IL-1. NIK associates with, and is a costimulator for IkB kinase a (IKKa). IKKa , in turn, phosphorylates IkB, resulting in I k B degradation and NF k B activation. NIK has sequence similarity to several kinases that participate in MAP kinase cascades. - FLSVL (Additional S&H Or Hazmat Fees May Apply)